Pub. Date : 2017 Jun
PMID : 28508124
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DNA hypermethylation of sFRP5 contributes to indoxyl sulfate-induced renal fibrosis. | Indican | secreted frizzled related protein 5 | Homo sapiens |
| 2 | In vitro investigations in human renal tubular HK-2 cells revealed that indoxyl sulfate exhibited a potent ability to induce Wnt/beta-catenin activation through the downregulation of sFRP5, a gene that codes for an extracellular antagonist of Wnt signaling, by increasing the DNA methylation level of its promoter CpG islands. | Indican | secreted frizzled related protein 5 | Homo sapiens |
| 3 | The increased expression of DNA methyltransferases following the activation of ROS/ERK1/2 signaling was responsible for the DNA hypermethylation of sFRP5 induced by indoxyl sulfate. | Indican | secreted frizzled related protein 5 | Homo sapiens |
| 4 | Conversely, treatment with 5-aza-2"-deoxycytidine, an inhibitor of DNA methyltransferases, significantly reduced indoxyl sulfate-induced sFRP5 downregulation and Wnt/beta-catenin activation. | Indican | secreted frizzled related protein 5 | Homo sapiens |
| 5 | Our results suggest that indoxyl sulfate promotes renal fibrosis through the induction of DNA hypermethylation of sFRP5, and thereafter the activation of Wnt/beta-catenin signaling. | Indican | secreted frizzled related protein 5 | Homo sapiens |