PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28508124-0	2017	DNA hypermethylation of sFRP5 contributes to indoxyl sulfate-induced renal fibrosis.	Indican	45-60	secreted frizzled related protein 5	Homo sapiens	24-29	
28508124-4	2017	In vitro investigations in human renal tubular HK-2 cells revealed that indoxyl sulfate exhibited a potent ability to induce Wnt/beta-catenin activation through the downregulation of sFRP5, a gene that codes for an extracellular antagonist of Wnt signaling, by increasing the DNA methylation level of its promoter CpG islands.	Indican	72-87	secreted frizzled related protein 5	Homo sapiens	183-188	
28508124-5	2017	The increased expression of DNA methyltransferases following the activation of ROS/ERK1/2 signaling was responsible for the DNA hypermethylation of sFRP5 induced by indoxyl sulfate.	Indican	165-180	secreted frizzled related protein 5	Homo sapiens	148-153	
28508124-6	2017	Conversely, treatment with 5-aza-2"-deoxycytidine, an inhibitor of DNA methyltransferases, significantly reduced indoxyl sulfate-induced sFRP5 downregulation and Wnt/beta-catenin activation.	Indican	113-128	secreted frizzled related protein 5	Homo sapiens	137-142	
28508124-8	2017	Our results suggest that indoxyl sulfate promotes renal fibrosis through the induction of DNA hypermethylation of sFRP5, and thereafter the activation of Wnt/beta-catenin signaling.	Indican	25-40	secreted frizzled related protein 5	Homo sapiens	114-119