Title : First-in-Man Demonstration of Direct Endothelin-Mediated Natriuresis and Diuresis.

Pub. Date : 2017 Jul

PMID : 28507171






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Big ET-1 increased the fractional excretion of sodium (from 0.5 to 1.0%). Sodium endothelin 1 Homo sapiens
2 Sodium and water excretion increased in the absence of significant hemodynamic perturbation, supporting a direct action of ET-1 on the renal tubule. Sodium endothelin 1 Homo sapiens
3 Our data also suggest that sodium reabsorption is stimulated by ET-1 in the thick ascending limb and suppressed in the distal renal tubule. Sodium endothelin 1 Homo sapiens