Title : β2-AR activation induces chemoresistance by modulating p53 acetylation through upregulating Sirt1 in cervical cancer cells.

Pub. Date : 2017 Jul

PMID : 28498637






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1 In the present study, we demonstrated that catecholamines upregulated the expression of silent information regulator 1 (Sirt1) through activating beta2-AR-mediated signaling pathway, since selective beta2-AR antagonist ICI 118, 551 and non-selective beta-blocker proprenolol effectively repressed isoproterenol (ISO)-induced Sirt1 expression. Isoproterenol adrenoceptor beta 2 Homo sapiens