Pub. Date : 2018 Feb
PMID : 28488786
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gadoxetic acid-enhanced magnetic resonance imaging reflects co-activation of beta-catenin and hepatocyte nuclear factor 4alpha in hepatocellular carcinoma. | gadolinium ethoxybenzyl DTPA | catenin beta 1 | Homo sapiens |
| 2 | AIM: The aim of this study is to clarify the correlation of the co-activation of beta-catenin and hepatocyte nuclear factor (HNF)4alpha with the findings of gadoxetic acid-enhanced magnetic resonance imaging (MRI), organic anion transporting polypeptide (OATP)1B3 expression, and histological findings in hepatocellular carcinoma (HCC). | gadolinium ethoxybenzyl DTPA | catenin beta 1 | Homo sapiens |
| 3 | RESULTS: Enhancement ratio on gadoxetic acid-enhanced MRI in HCC with beta-catenin/GS (+) HNF4alpha (+) was significantly higher than those of the other three groups (P < 0.001). | gadolinium ethoxybenzyl DTPA | catenin beta 1 | Homo sapiens |
| 4 | CONCLUSION: Co-activation of beta-catenin and HNF4alpha would promote OATP1B3 expression, and consequently higher enhancement ratio on gadoxetic acid-enhanced MRI and higher differentiation grade in HCC. | gadolinium ethoxybenzyl DTPA | catenin beta 1 | Homo sapiens |