Pub. Date : 2017 Jul
PMID : 28486190
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Icariin (0.1muM) upregulated TAZ, Runx2, beta-catenin, Osteopotin, and Dlx5 expression mainly at the early stage of osteogenic differentiation, and increased osteocalcin expression at the late stage. | icariin | catenin beta 1 | Rattus norvegicus |
| 2 | Moreover, ICI 182780 (the estrogen receptor alpha inhibitor) or DKK1 (the Wnt/beta-catenin pathway inhibitor), inhibited the icariin-induced increase in TAZ expression. | icariin | catenin beta 1 | Rattus norvegicus |
| 3 | Taken together, our results demonstrate that icariin promotes the osteogenic differentiation of rBMSCs by increasing TAZ expression, and that the increased TAZ expression induced by icariin is mostly mediated by the ERalpha and Wnt/beta-catenin pathway. | icariin | catenin beta 1 | Rattus norvegicus |