Title : Inhibition of cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferases by MAM-2201 in human liver microsomes.

Pub. Date : 2017 Jun

PMID : 28484907






1 Functional Relationships(s)
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1 MAM-2201 potently inhibited CYP2C9-catalyzed diclofenac 4"-hydroxylation, CYP3A4-catalyzed midazolam 1"-hydroxylation, and UGT1A3-catalyzed chenodeoxycholic acid 24-acyl-glucuronidation, with K i values of 5.6, 5.4 and 5.0 microM, respectively. Diclofenac cytochrome P450 family 2 subfamily C member 9 Homo sapiens