Title : In vitro and in vivo pharmacology of NXT629, a novel and selective PPARα antagonist.

Pub. Date : 2017 Aug 15

PMID : 28483457






2 Functional Relationships(s)
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1 Under conditions of metabolic stress such as fasting or glucose deprivation, PPARalpha is upregulated in order to control gene expression necessary for processing alternate fuel sources (e.g. fatty acid oxidation) and thereby promote maintenance of cell viability. Fatty Acids peroxisome proliferator activated receptor alpha Homo sapiens
2 We believe that PPARalpha antagonists will be beneficial in diseases such as ovarian cancer and melanoma where PPARalpha and fatty acid oxidation may be involved. Fatty Acids peroxisome proliferator activated receptor alpha Homo sapiens