Title : Impact of FDA-Approved Drugs on the Prostaglandin Transporter OATP2A1/SLCO2A1.

Pub. Date : 2017 Sep

PMID : 28479361






2 Functional Relationships(s)
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1 Inhibitory affinity of suramin to OATP2A1 was the highest (IC50,2A1 of 0.17 muM), and its IC50 values to MRP4-mediated PGE2 transport (IC50,MRP4) and PGE2 synthesis in human U-937 cells treated with phorbol 12-myristate 13-acetate (IC50,Syn) were 73.6 and 336.7 times higher than IC50,2A1, respectively. Dinoprostone ATP binding cassette subfamily C member 4 Homo sapiens
2 Inhibitory affinity of suramin to OATP2A1 was the highest (IC50,2A1 of 0.17 muM), and its IC50 values to MRP4-mediated PGE2 transport (IC50,MRP4) and PGE2 synthesis in human U-937 cells treated with phorbol 12-myristate 13-acetate (IC50,Syn) were 73.6 and 336.7 times higher than IC50,2A1, respectively. Dinoprostone ATP binding cassette subfamily C member 4 Homo sapiens