Title : Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data.

Pub. Date : 2017 Sep

PMID : 28479356






2 Functional Relationships(s)
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1 The time profiles of RPG and the inhibitors were analyzed by PBPK models, considering the inhibition of OATP1B1 and CYP3A4 by CsA or OATP1B1 inhibition by GEM and its glucuronide and the mechanism-based inhibition of CYP2C8 by GEM glucuronide. Cyclosporine solute carrier organic anion transporter family member 1B1 Homo sapiens
2 RPG-CsA interaction was closely predicted using a reported in vitro Ki,OATP1B1 value in the presence of CsA preincubation. Cyclosporine solute carrier organic anion transporter family member 1B1 Homo sapiens