Title : Successful metformin treatment of insulin resistance is associated with down-regulation of the kynurenine pathway.

Pub. Date : 2017 Jun 17

PMID : 28478038






1 Functional Relationships(s)
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1 CONTEXT: An extensive body of literature indicates a relationship between insulin resistance and the up-regulation of the kynurenine pathway, i.e. the preferential conversion of tryptophan to kynurenine, with subsequent overproduction of diabetogenic downstream metabolites, such as kynurenic acid. Tryptophan insulin Homo sapiens