Title : Novel Mode of Antagonist Binding in NMDA Receptors Revealed by the Crystal Structure of the GluN1-GluN2A Ligand-Binding Domain Complexed to NVP-AAM077.

Pub. Date : 2017 Jul

PMID : 28468946






2 Functional Relationships(s)
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1 In this study, we present the crystal structure of the isolated ligand-binding domain of the GluN1-GluN2A NMDA receptor in complex with the GluN1 agonist glycine and the GluN2A antagonist NVP-AAM077. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens
2 In this study, we present the crystal structure of the isolated ligand-binding domain of the GluN1-GluN2A NMDA receptor in complex with the GluN1 agonist glycine and the GluN2A antagonist NVP-AAM077. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens