Title : Insulin activation of cyclic AMP phosphodiesterase in intact ureteral segments.

Pub. Date : 1988 Nov

PMID : 2846825






1 Functional Relationships(s)
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1 Although the insulin-increased cAMP PDE exhibits the same sensitivity as control PDE from untreated preparations to isobutylmethyl xanthine, a nonspecific PDE inhibitor, and M & B 22,948, a relatively selective cyclic GMP PDE inhibitor, differences in the degree of inhibition of PDE activity are seen in the insulin-treated and untreated preparations with the low Km cAMP PDE inhibitors Ro20-1724, rolipram, amrinone and milrinone and with cyclic GMP. Milrinone insulin Homo sapiens