Title : Activation of transforming growth factor-β1 by thrombin via integrins αvβ1, αvβ3, and αvβ5 in buccal fibroblasts: Suppression by epigallocatechin-3-gallate.

Pub. Date : 2017 Jul

PMID : 28464379






1 Functional Relationships(s)
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1 Neutralizing antibodies to integrin alphav, beta1, alphavbeta3, alphavbeta5, and Rho-associated coiled-coil forming protein kinase (ROCK) inhibitor Y27632 completely blocked thrombin-induced TGF-beta1 activation, Smad3 phosphorylation, and CCN2 synthesis. Y 27632 coagulation factor II, thrombin Homo sapiens