Title : Alterations in chemotactic factor-induced responses of neutrophils and monocytes from chronic dialysis patients.

Pub. Date : 1988 Aug

PMID : 2846218






5 Functional Relationships(s)
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1 Superoxide anion production by PMN and monocytes from HD and CAPD patients in response to C5a and fMLP was also significantly decreased compared to controls. Superoxides complement C5a receptor 1 Homo sapiens
2 PMN superoxide production in response to C5a was decreased by an average of 36.5% (p less than 0.001) for HD patients and 32.0% (p less than 0.001) for CAPD patients. Superoxides complement C5a receptor 1 Homo sapiens
3 This decreased responsiveness was restricted to C5a- and fMLP-stimulated superoxide production since phorbol myristate acetate (PMA)-stimulated responses were comparable to controls. Superoxides complement C5a receptor 1 Homo sapiens
4 Analysis of the binding of fluorescent C5a to PMN showed a direct correlation between decreased C5a binding and decreased O2- production and MPO release. Superoxides complement C5a receptor 1 Homo sapiens
5 Analysis of the binding of fluorescent C5a to PMN showed a direct correlation between decreased C5a binding and decreased O2- production and MPO release. Superoxides complement C5a receptor 1 Homo sapiens