Title : Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies.

Pub. Date : 2017 Apr 18

PMID : 28460441






1 Functional Relationships(s)
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1 We demonstrate the efficacy of the off-patent drug disulfiram when chelated with copper, which we had previously reported to inhibit NFkappaB signaling, was highly effective in disrupting both IBC spheroids and emboli grown in vitro. Disulfiram nuclear factor kappa B subunit 1 Homo sapiens