Title : Celastrol reduces IL-1β induced matrix catabolism, oxidative stress and inflammation in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration in vivo.

Pub. Date : 2017 Jul

PMID : 28458159






1 Functional Relationships(s)
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1 Our results showed that celastrol reduced the expression of catabolic genes (MMP-3, 9, 13, ADAMTS-4, 5), oxidative stress factors (COX-2, iNOS) and pro-inflammatory factors (IL-6, TNF-a) induced by IL-1beta in nucleus pulposus cells, also phosphorylation of IkappaBalpha and p65 were attenuated by celastrol, indicating NF-kappaB pathway was inhibited by celastrol in nucleus pulposus cells. celastrol interleukin 6 Rattus norvegicus