Title : Importance of the novel organic cation transporter 1 for tyrosine kinase inhibition by saracatinib in rheumatoid arthritis synovial fibroblasts.

Pub. Date : 2017 Apr 28

PMID : 28455521






1 Functional Relationships(s)
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1 Since intracellular effective TKIs must enter the cell to reach their intracellular targets, here we investigated the interaction of the TKI saracatinib, a dual inhibitor of c-Src and c-Abl signaling, with transporters for organic cations as well as the role of these transporters for the biological effect of saracatinib in human RA-synovial fibroblasts (hRASF). saracatinib SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens