Title : YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2.

Pub. Date : 2017 Apr 27

PMID : 28449688






3 Functional Relationships(s)
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1 YY-1224 significantly attenuated learning impairment, Abeta deposition, and pro-inflammatory microglial activation in APP/PS1 Tg mice, whereas it significantly enhanced PAF-AH and PPARgamma expression. yy-1224 amyloid beta (A4) precursor protein Mus musculus
2 The protective activity of YY-1224 appeared to be more efficacious than a standard G. biloba extract (Gb) against Abeta insult. yy-1224 amyloid beta (A4) precursor protein Mus musculus
3 CONCLUSIONS: Our results suggest that the protective effects of YY-1224 against Abeta toxicity may be associated with its PAF antagonistic- and PPARgamma agonistic-potential as well as inhibition of the Abeta-mediated pro-inflammatory switch of microglia phenotypes through suppression of COX-2 expression. yy-1224 amyloid beta (A4) precursor protein Mus musculus