Pub. Date : 2017 Aug
PMID : 28445587
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CB1 receptors down-regulate a cAMP/Epac2/PLC pathway to silence the nerve terminals of cerebellar granule cells. | Cyclic AMP | cannabinoid receptor 1 | Homo sapiens |
| 2 | Adopting a combined pharmacological and genetic approach to study the molecular mechanisms of CB1R-induced silencing, we found that adenylyl cyclase inhibition decreases cAMP levels while it increases the number of silent synaptic boutons and occludes the induction of further silencing by the cannabinoid agonist HU-210. | Cyclic AMP | cannabinoid receptor 1 | Homo sapiens |