Pub. Date : 2017 Jun
PMID : 28440398
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lycopene inhibits NF-kappaB activation and adhesion molecule expression through Nrf2-mediated heme oxygenase-1 in endothelial cells. | Lycopene | heme oxygenase 1 | Homo sapiens |
| 2 | Subsequently, lycopene induced nuclear factor-erythroid 2 related factor 2 (Nrf2) activation, leading to the increased expression of downstream of heme oxygenase-1 (HO-1). | Lycopene | heme oxygenase 1 | Homo sapiens |
| 3 | Subsequently, lycopene induced nuclear factor-erythroid 2 related factor 2 (Nrf2) activation, leading to the increased expression of downstream of heme oxygenase-1 (HO-1). | Lycopene | heme oxygenase 1 | Homo sapiens |
| 4 | The use of siRNA targeting HO-1 blocked the inhibitory effects of lycopene on IkappaB degradation and ICAM-1 expression. | Lycopene | heme oxygenase 1 | Homo sapiens |
| 5 | The inhibitory effects of lycopene thus appear to be mediated through its induction of Nrf2-mediated HO-1 expression. | Lycopene | heme oxygenase 1 | Homo sapiens |
| 6 | Therefore, the findings of the present study indicate that lycopene suppresses the activation of TNFalpha-induced signaling pathways through the upregulation of Nrf2-mediated HO-1 expression. | Lycopene | heme oxygenase 1 | Homo sapiens |