Title : Convergent ERK1/2, p38 and JNK mitogen activated protein kinases (MAPKs) signalling mediate catecholoestradiol-induced proliferation of ovine uterine artery endothelial cells.

Pub. Date : 2017 Jul 15

PMID : 28437005






4 Functional Relationships(s)
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1 Herein we show that activation of ERK1/2, p38 and JNK mitogen activated protein kinases (MAPKs) is necessary for 2-OHE2 - and 4-OHE2 -induced P-UAEC proliferation, as well as proliferation induced by the parent hormone E2 beta and other beta-AR signalling hormones (i.e. catecholamines). 2-hydroxyestradiol mitogen-activated protein kinase 1 Homo sapiens
2 Herein we show that activation of ERK1/2, p38 and JNK mitogen activated protein kinases (MAPKs) is necessary for 2-OHE2 - and 4-OHE2 -induced P-UAEC proliferation, as well as proliferation induced by the parent hormone E2 beta and other beta-AR signalling hormones (i.e. catecholamines). 2-hydroxyestradiol mitogen-activated protein kinase 1 Homo sapiens
3 2-OHE2 and 4-OHE2 stimulated biphasic phosphorylation of ERK1/2, slow p38 and JNK phosphorylation over time, and rapid monophasic AKT phosphorylation. 2-hydroxyestradiol mitogen-activated protein kinase 1 Homo sapiens
4 2-OHE2 and 4-OHE2 stimulated biphasic phosphorylation of ERK1/2, slow p38 and JNK phosphorylation over time, and rapid monophasic AKT phosphorylation. 2-hydroxyestradiol mitogen-activated protein kinase 1 Homo sapiens