Title : Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin-related protein 1.

Pub. Date : 2017

PMID : 28435473






3 Functional Relationships(s)
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1 The present study also found that inhibition of mitochondrial COX-2 with resveratrol (RSV), a natural phytochemical, increased the sensitivity of NPC to 5-fluorouracil (5-FU), a classical chemotherapy drug for NPC. Resveratrol prostaglandin-endoperoxide synthase 2 Homo sapiens
2 The present study also found that inhibition of mitochondrial COX-2 with resveratrol (RSV), a natural phytochemical, increased the sensitivity of NPC to 5-fluorouracil (5-FU), a classical chemotherapy drug for NPC. Resveratrol prostaglandin-endoperoxide synthase 2 Homo sapiens
3 The underlying mechanism is that RSV suppresses mitochondrial COX-2, thereby reducing NPC stemness by inhibiting Drp1 activity as demonstrated in both the in vitro and the in vivo studies. Resveratrol prostaglandin-endoperoxide synthase 2 Homo sapiens