Pub. Date : 2017 Jun
PMID : 28433514
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interestingly, recruitment of CD4+T cells and F4/80+ macrophages as well as BMSC transplantation induced up-regulation of Cox-2 and IL-17A gene expression levels were reverted by celecoxib administration. | Celecoxib | interleukin 17A | Mus musculus |
| 2 | Conditioned media of rIL-17 treated J774.2 cells when supplemented to BMSCs depicted a dose-dependent increase in the number of apoptotic cells and proapoptotic protein expression that was perturbed by celecoxib or IL-17 neutralizing antibody. | Celecoxib | interleukin 17A | Mus musculus |
| 3 | CONCLUSION: Celecoxib protects transplanted BMSCs from Cox-2/IL-17-induced inflammation and increases their engraftment, differentiation into keratinocytes and re-epithelialization thereby potentiating wound tissue repair. | Celecoxib | interleukin 17A | Mus musculus |