Protein Name interleukin 17A
Organism Mus musculus
Gene ID 16171
Gene Symbol

Il17a

UniProt Q62386 (IL17_MOUSE), Q544E6 (Q544E6_MOUSE)
Relationships Total Number of functionally related compound(s) : 1009
Total Number of Articles : 1548
Description

interleukin 17A

Gene Summary

This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]

synonyms
  • interleukin-17A
  • cytotoxic T-lymphocyte-associated antigen 8
  • Ctla-8
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Properties