Title : Rotundarpene inhibits TNF-α-induced activation of the Akt, mTOR, and NF-κB pathways, and the JNK and p38 associated with production of reactive oxygen species.

Pub. Date : 2017 Oct

PMID : 28432555






1 Functional Relationships(s)
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1 Inhibitors of the c-JNK (SP600125) and p38-MAPK (SB203580) reduced the TNF-alpha-induced production of inflammatory mediators, binding of NF-kappaB to DNA, and activation of the JNK and p38-MAPK in keratinocytes. SB 203580 nuclear factor kappa B subunit 1 Homo sapiens