Pub. Date : 2017 Jul
PMID : 28432535
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exploring the Carbamazepine Interaction with Human Pregnane X Receptor and Effect on ABCC2 Using in Vitro and in Silico Approach. | Carbamazepine | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 2 | METHODS: We investigated the effect of CBZ on expression of ABCC2 and pregnane X receptor (PXR) in HepG2 cell line and compared with hyperforin (agonist of PXR) and ketoconazole (antagonist of PXR) through realtime PCR and western blot assay. | Carbamazepine | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 3 | METHODS: We investigated the effect of CBZ on expression of ABCC2 and pregnane X receptor (PXR) in HepG2 cell line and compared with hyperforin (agonist of PXR) and ketoconazole (antagonist of PXR) through realtime PCR and western blot assay. | Carbamazepine | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 4 | Molecular docking and dynamic simulation approach was used to understand the interaction of CBZ with PXR. | Carbamazepine | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 5 | Molecular dynamic (MD) simulation and in vitro experiment indicated possibility of CBZ to be PXR agonist and PXR residue Gln285 to be important for CBZ-PXR interaction. | Carbamazepine | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 6 | Molecular dynamic (MD) simulation and in vitro experiment indicated possibility of CBZ to be PXR agonist and PXR residue Gln285 to be important for CBZ-PXR interaction. | Carbamazepine | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 7 | Molecular dynamic (MD) simulation and in vitro experiment indicated possibility of CBZ to be PXR agonist and PXR residue Gln285 to be important for CBZ-PXR interaction. | Carbamazepine | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
| 8 | CONCLUSIONS: CBZ alters the functional activity of ABCC2 through PXR, which in turn can interfere with therapy. | Carbamazepine | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |