Title : Clozapine reduces Toll-like receptor 4/NF-κB-mediated inflammatory responses through inhibition of calcium/calmodulin-dependent Akt activation in microglia.

Pub. Date : 2018 Feb 2

PMID : 28431901






1 Functional Relationships(s)
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1 In this study, we found that clozapine suppressed lipopolysaccharide (LPS)-induced phosphorylation of IkappaBalpha at Ser-32 and of p65/RelA at Ser-468, as well as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB)-dependent transcriptional activity in microglial cells. Serine NFKB inhibitor alpha Homo sapiens