Title : Ketamine administered pregnant rats impair learning and memory in offspring via the CREB pathway.

Pub. Date : 2017 May 16

PMID : 28430606






2 Functional Relationships(s)
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1 The results revealed that ketamine impaired the learning ability and spatial as well as conditioned memory in the offspring, and significantly decreased the protein levels of ERK, p-ERK, PKA, p-PKA, p-CREB, and BDNF. Ketamine brain-derived neurotrophic factor Rattus norvegicus
2 We found that ERK and PKA (but not CaMKII or CaMKIV) have the ability to regulate the CREB-BDNF pathway during ketamine-induced anesthesia in pregnant rats. Ketamine brain-derived neurotrophic factor Rattus norvegicus