Pub. Date : 2017 May
PMID : 28426124
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, propofol, a general anesthetic, was found to significantly reduce the LPS-induced upregulation of HIF-1alpha and ROS in a dose-dependent manner. | Propofol | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | Further study showed that propofol may antagonize the role of LPS in activating HIF-1alpha through attenuating the protein stability and nuclear localization of HIF-1alpha. | Propofol | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | Further study showed that propofol may antagonize the role of LPS in activating HIF-1alpha through attenuating the protein stability and nuclear localization of HIF-1alpha. | Propofol | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 4 | Consistently, a wound healing assay revealed that propofol abrogated LPS-stimulated migration of NSCLC cells while overexpression of HIF-1alpha reversed the effects of propofol. | Propofol | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 5 | However, results from the Transwell assay confirmed that propofol also suppressed cell invasion by decreasing HIF-1alpha expression in the LPS-treated NSCLC cells. | Propofol | hypoxia inducible factor 1 subunit alpha | Homo sapiens |