Title : Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer.

Pub. Date : 2017 May 1

PMID : 28414297






1 Functional Relationships(s)
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1 In a KRAS-induced orthotopic PDAC model, coadministration of iRGD enhanced the uptake of an irinotecan-loaded silicasome carrier that comprises lipid bilayer-coated mesoporous silica nanoparticles (MSNPs); this uptake resulted in enhanced survival and markedly reduced metastasis. Irinotecan KRAS proto-oncogene, GTPase Homo sapiens