Title : Decrease in the Generation of Amyloid-β Due to Salvianolic Acid B by Modulating BACE1 Activity.

Pub. Date : 2017

PMID : 28413985






1 Functional Relationships(s)
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1 Using N2a-mouse and H4- human neuroglioma cell lines expressing SwedAPP, it was demonstrated that Sal B significantly and dose-dependently decreased the generation of extracellular Abeta, soluble APPbeta (by-product of APP cleaved by BACE1), and intracellular C-terminal fragment beta from APP without influencing alpha-secretase and gamma-secretase activity and the levels of FL-APP. salvianolic acid B amyloid beta precursor protein Homo sapiens