Title : Vandetanib and ADAM inhibitors synergistically attenuate the pathological migration of EBV-infected retinal pigment epithelial cells by regulating the VEGF-mediated MAPK pathway.

Pub. Date : 2017 Apr

PMID : 28413487






1 Functional Relationships(s)
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1 Furthermore, co-treatment with vandetanib and an ADAM10 inhibitor (GI254023X) or ADAM17 inhibitor (Marimastat) synergistically prevented migration and the expression of vimentin, Snail and alpha-smooth muscle actin by regulating extracellular signal-regulated kinase and p38 mitogen-activated protein kinase. vandetanib mitogen-activated protein kinase 14 Homo sapiens