Pub. Date : 2017 Jun
PMID : 28391159
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-kB/IkBalpha, p38 MAPK, and Bcl-2/Bax signaling. | Quercetin | BCL2, apoptosis regulator | Rattus norvegicus |
| 2 | Additionally, in a dose-dependent manner, quercetin down-regulated Bax, up-regulated Bcl-2, and subsequently inhibited caspase-3 activation. | Quercetin | BCL2, apoptosis regulator | Rattus norvegicus |
| 3 | The anti-fibrotic mechanisms of quercetin might be associated with its ability to regulate NF-kB/IkBalpha, p38 MAPK anti-inflammation signaling pathways to inhibit inflammation, and regulate Bcl-2/Bax anti-apoptosis signaling pathway to prevent liver cell apoptosis. | Quercetin | BCL2, apoptosis regulator | Rattus norvegicus |