Pub. Date : 2017 May 19
PMID : 28373282
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity. | Metformin | high mobility group box 1 | Homo sapiens |
| 2 | Here we identified HMGB1 as a novel metformin-binding protein by affinity purification using a biotinylated metformin analogue. | Metformin | high mobility group box 1 | Homo sapiens |
| 3 | Metformin directly bound to the C-terminal acidic tail of HMGB1. | Metformin | high mobility group box 1 | Homo sapiens |
| 4 | Both in vitro and in vivo, metformin inhibited inflammatory responses induced by full-length HMGB1 but not by HMGB1 lacking the acidic tail. | Metformin | high mobility group box 1 | Homo sapiens |
| 5 | In an acetaminophen-induced acute liver injury model in which HMGB1 released from injured cells exacerbates the initial injury, metformin effectively reduced liver injury and had no additional inhibitory effects when the extracellular HMGB1 was blocked by anti-HMGB1-neutralizing antibody. | Metformin | high mobility group box 1 | Homo sapiens |
| 6 | In an acetaminophen-induced acute liver injury model in which HMGB1 released from injured cells exacerbates the initial injury, metformin effectively reduced liver injury and had no additional inhibitory effects when the extracellular HMGB1 was blocked by anti-HMGB1-neutralizing antibody. | Metformin | high mobility group box 1 | Homo sapiens |
| 7 | In summary, we report for the first time that metformin suppresses inflammation by inhibiting the extracellular activity of HMGB1. | Metformin | high mobility group box 1 | Homo sapiens |