Title : Autoinhibitory properties of the parent but not of the N-oxide metabolite contribute to infusion rate-dependent voriconazole pharmacokinetics.

Pub. Date : 2017 Sep

PMID : 28370390






3 Functional Relationships(s)
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1 Voriconazole-N-oxide inhibition of cytochrome P450 (CYP) isoforms 2C19 and 3A4 were assessed with the P450-Glo luminescence assay. Voriconazole N-Oxide cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 Voriconazole-N-oxide inhibition of cytochrome P450 (CYP) isoforms 2C19 and 3A4 were assessed with the P450-Glo luminescence assay. Voriconazole N-Oxide cytochrome P450 family 4 subfamily F member 3 Homo sapiens
3 Concentration giving 50% CYP inhibition of voriconazole N-oxide was 146 +- 23 mumol l-1 for CYP3A4, and 40.2 +- 4.2 mumol l-1 for CYP2C19. Voriconazole N-Oxide cytochrome P450 family 4 subfamily F member 3 Homo sapiens