Pub. Date : 2017 Jun
PMID : 28359840
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Similarly, in SAMHD1 knockout cells, HIV-1 showed increased replicative capacity in the presence of nucleoside inhibitors, especially AZT, that was reverted by re-expression of wild type SAMHD1. | Nucleosides | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |
| 2 | Similarly, in SAMHD1 knockout cells, HIV-1 showed increased replicative capacity in the presence of nucleoside inhibitors, especially AZT, that was reverted by re-expression of wild type SAMHD1. | Nucleosides | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |
| 3 | Our results demonstrate that SAMHD1 is active in HIV-1 permissive cells, does not modify susceptibility to HIV-1 infection but strongly affects sensitivity to nucleoside inhibitors. | Nucleosides | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Homo sapiens |