Pub. Date : 2017 Feb
PMID : 28356955
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ursolic acid sensitizes radioresistant NSCLC cells expressing HIF-1alpha through reducing endogenous GSH and inhibiting HIF-1alpha. | ursolic acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | Ursolic acid sensitizes radioresistant NSCLC cells expressing HIF-1alpha through reducing endogenous GSH and inhibiting HIF-1alpha. | ursolic acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | The irradiated H1299/M-HIF-1alpha cells were more sensitive to UA pretreatment than the irradiated cells with empty plasmid and control. | ursolic acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 4 | The results revealed that UA treatment alone could effectively decrease the GSH content in H1299/M-HIF-1alpha cells. | ursolic acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 5 | It was then concluded that UA could upregulate the radiosensitivity of NSCLC cells, and in particular reduce the refractory response of cells expressing HIF-1alpha to ionizing radiation. | ursolic acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |