Pub. Date : 2017 Apr
PMID : 28350522
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AIM: To investigate the combined effects of SLCO1B1 and ABCB1 genotypes on the pharmacokinetics of simvastatin and its active metabolite simvastatin acid, in relation to CYP3A4 inhibition. | simvastatin acid | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 2 | RESULTS: The SLCO1B1 c.521T>C variant significantly increased exposure to simvastatin acid by around 40% (p < 0.05), similar to that caused by the amlodipine pretreatment. | simvastatin acid | solute carrier organic anion transporter family member 1B1 | Homo sapiens |