Title : Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in vivo anti-tumor activity.

Pub. Date : 2017 May 26

PMID : 28340412






1 Functional Relationships(s)
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1 Two co-crystal structures of compounds 11b and 15e complexed with PARP-1 were achieved and demonstrated a unique binding mode of these benzo-imidazole derivatives. benzimidazole poly(ADP-ribose) polymerase 1 Homo sapiens