Pub. Date : 2017 May 1
PMID : 28324042
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Objectives: We hypothesized that in obesity IL-1 antagonism would result in downregulation of the hypothalamo-pituitary-adrenal axis, leading to decreased cortisol levels. | Hydrocortisone | interleukin 1 beta | Homo sapiens |
| 2 | Median morning serum cortisol levels (nmol/L) decreased significantly after IL-1 antagonism [from baseline, 452 to 423; absolute difference, -38.7; 95% confidence interval (CI), -64 to -13.4; P = 0.0019]. | Hydrocortisone | interleukin 1 beta | Homo sapiens |