Pub. Date : 2017 Jun
PMID : 28286920
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge. | dapt | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 2 | However, TLR4 KO mice that received DAPT reduced APAP-induced liver damage and NF-kappaB, NLRP3, and cleaved caspase-1 activation. | dapt | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |