Title : Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement.

Pub. Date : 2017 May

PMID : 28282788






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1 In the present study, we showed that berberine (BBR) significantly suppressed saturated fatty acid palmitate (PA)-induced NLRP3 inflammasome activation and interleukin-1beta (IL-1beta) release in macrophages, which was one of the most important mediators in the insulin sensitivity of adipose tissue. saturated fatty acid palmitate NLR family, pyrin domain containing 3 Mus musculus