Pub. Date : 2017 May 15
PMID : 28279662
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study investigated PPARalpha as a possible mediator of the effect of alpha7 nAChR activation in nicotine dependence. | Nicotine | peroxisome proliferator activated receptor alpha | Mus musculus |
| 2 | Our results demonstrate the PPARalpha antagonist GW6471 blocks actions of the alpha7 nAChR agonist PNU282987 on nicotine reward in an unbiased CPP test in male ICR adult mice. | Nicotine | peroxisome proliferator activated receptor alpha | Mus musculus |
| 3 | These findings suggests that alpha7 nAChR activation attenuates nicotine CPP in a PPARalpha-dependent manner. | Nicotine | peroxisome proliferator activated receptor alpha | Mus musculus |
| 4 | To evaluate PPARalpha activation in nicotine dependence we used the selective and potent PPARalpha agonist, WY-14643 and the clinically used PPARalpha activator, fenofibrate, in nicotine CPP and we observed attenuation of nicotine preference, but fenofibrate was less potent. | Nicotine | peroxisome proliferator activated receptor alpha | Mus musculus |
| 5 | We also studied PPARalpha in nicotine dependence by evaluating its activation in nicotine withdrawal. | Nicotine | peroxisome proliferator activated receptor alpha | Mus musculus |
| 6 | We also studied PPARalpha in nicotine dependence by evaluating its activation in nicotine withdrawal. | Nicotine | peroxisome proliferator activated receptor alpha | Mus musculus |
| 7 | This suggests that PPARalpha plays a role in nicotine reward and withdrawal and that further studies are warranted to elucidate its function in mediating the effects of alpha7 nAChRs in nicotine dependence. | Nicotine | peroxisome proliferator activated receptor alpha | Mus musculus |
| 8 | This suggests that PPARalpha plays a role in nicotine reward and withdrawal and that further studies are warranted to elucidate its function in mediating the effects of alpha7 nAChRs in nicotine dependence. | Nicotine | peroxisome proliferator activated receptor alpha | Mus musculus |