Pub. Date : 2017 Dec
PMID : 28277073
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enhancement of vascular endothelial growth factor"s angiogenic capacity by the therapeutic modulation of notch signalling improves tram flap survival in rats submitted to nicotine. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |
| 2 | Considering that Notch signalling through its ligand Delta-like 4 (Dll4) functions as anti-angiogenic factor by inhibiting the pro-angiogenic effects of vascular endothelial growth factor (VEGF), it is hypothesised that inhibition of the Notch would promote angiogenesis and increase TRAM flap survival in rats submitted to nicotine. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |
| 3 | CONCLUSION: Notch inhibition significantly improved TRAM flap survival in animals exposed to nicotine by promoting VEGF-induced angiogenesis. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |