Title : Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion.

Pub. Date : 2016 Mar

PMID : 28276667






1 Functional Relationships(s)
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1 Selective reversal of multi-drug resistance (MDR), decreased efflux of doxorubicin, and fluorescent substrates were demonstrated by sulindac sulfide and a related NSAID, indomethacin, in resistance selected and engineered cell lines expressing ABCC1, but not ABCB1 or ABCG2. Indomethacin ATP binding cassette subfamily C member 1 Homo sapiens