Title : Pheomelanogenesis is promoted at a weakly acidic pH.

Pub. Date : 2017 May

PMID : 28271633






2 Functional Relationships(s)
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1 The oxidation of tyrosine by tyrosinase in the presence of cysteine forms cysteinyldopa isomers, which are further oxidized to give rise to pheomelanin via benzothiazine intermediates. Cysteine tyrosinase Homo sapiens
2 We found that pheomelanin production either from dopa or tyrosine in the presence of cysteine by tyrosinase was greatest at pH values of 5.8-6.3, while eumelanin production was suppressed at pH 5.8. Cysteine tyrosinase Homo sapiens