Pub. Date : 2017 Oct 1
PMID : 28263721
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hepatoprotective effect of 7-Hydroxycoumarin against Methyl glyoxal toxicity via activation of Nrf2. | Pyruvaldehyde | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Results show that 7-HC pretreatment significantly attenuates MG-induced cytotoxicity, apoptotic changes and ROS accumulation and that this protection is shown to be associated with the induction of the nuclear factor erythroid 2-related factor 2 (NRF2) and its downstream detoxifying enzymes. | Pyruvaldehyde | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Results show that 7-HC pretreatment significantly attenuates MG-induced cytotoxicity, apoptotic changes and ROS accumulation and that this protection is shown to be associated with the induction of the nuclear factor erythroid 2-related factor 2 (NRF2) and its downstream detoxifying enzymes. | Pyruvaldehyde | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | In addition, depletion of NRF2 by siRNA significantly reduces the protective effect of 7-HC against MG, suggesting that NRF2 plays an important role in the protective function of 7-HC. | Pyruvaldehyde | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 5 | In addition, depletion of NRF2 by siRNA significantly reduces the protective effect of 7-HC against MG, suggesting that NRF2 plays an important role in the protective function of 7-HC. | Pyruvaldehyde | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 6 | These findings highlight the potential for the interventional activation of the NRF2 induction via the non-toxic natural phytochemical 7-HC as a novel therapeutic approach towards the detoxification of MG, with the aim of halting the progression of diseases in which MG has been implicated. | Pyruvaldehyde | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 7 | These findings highlight the potential for the interventional activation of the NRF2 induction via the non-toxic natural phytochemical 7-HC as a novel therapeutic approach towards the detoxification of MG, with the aim of halting the progression of diseases in which MG has been implicated. | Pyruvaldehyde | NFE2 like bZIP transcription factor 2 | Homo sapiens |