Pub. Date : 2017 Mar 3
PMID : 28256636
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice. | Fenretinide | fibroblast growth factor 21 | Mus musculus |
| 2 | Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice. | Fenretinide | fibroblast growth factor 21 | Mus musculus |
| 3 | Fenretinide normalised elevated levels of FGF21 in both high-fat diet-induced obese mice and in genetically obese-diabetic Leprdbmice. | Fenretinide | fibroblast growth factor 21 | Mus musculus |
| 4 | Moreover, Fenretinide-mediated suppression of FGF21 was independent of body weight loss or improved hepatic insulin sensitivity and importantly does not induce unhealthy metabolic complications. | Fenretinide | fibroblast growth factor 21 | Mus musculus |
| 5 | The repression of FGF21 levels by Fenretinide occurs by reduced binding of RARalpha and Pol-II at the Fgf21 promoter. | Fenretinide | fibroblast growth factor 21 | Mus musculus |
| 6 | The repression of FGF21 levels by Fenretinide occurs by reduced binding of RARalpha and Pol-II at the Fgf21 promoter. | Fenretinide | fibroblast growth factor 21 | Mus musculus |
| 7 | We therefore establish Fgf21 as a novel gene target of Fenretinide signalling via a retinoid-dependent mechanism. | Fenretinide | fibroblast growth factor 21 | Mus musculus |