Pub. Date : 2017 May 1
PMID : 28254774
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanism of salutary effects of melatonin-mediated liver protection after trauma-hemorrhage: p38 MAPK-dependent iNOS/HIF-1alpha pathway. | Melatonin | nitric oxide synthase 2 | Rattus norvegicus |
| 2 | This study explored whether melatonin prevents liver injury after trauma-hemorrhage through the p38 mitogen-activated protein kinase (MAPK)-dependent, inducible nitrite oxide (iNOS)/hypoxia-inducible factor (HIF)-1alpha pathway. | Melatonin | nitric oxide synthase 2 | Rattus norvegicus |
| 3 | Administration of melatonin after trauma-hemorrhage normalized liver p38 MAPK phosphorylation and iNOS and HIF-1alpha expression and attenuated cleaved caspase 3 and receptor interacting protein kinase-1 levels. | Melatonin | nitric oxide synthase 2 | Rattus norvegicus |
| 4 | Coadministration of SB203580 or luzindole abolished the melatonin-mediated attenuation of the trauma-hemorrhage-induced increase of iNOS/HIF-1alpha protein expression and liver injury markers. | Melatonin | nitric oxide synthase 2 | Rattus norvegicus |
| 5 | Taken together, our results suggest that melatonin prevents trauma-hemorrhage-induced liver injury in rats, at least in part, through melatonin receptor-related, p38 MAPK-dependent iNOS/HIF-1alpha pathway.NEW & NOTEWORTHY Trauma-hemorrhage resulted in a significant decrease in liver p38 MAPK activation and increase in nitrite oxide synthase (iNOS) and hypoxia-inducible factor (HIF)-1alpha expression. | Melatonin | nitric oxide synthase 2 | Rattus norvegicus |
| 6 | Taken together, our results suggest that melatonin prevents trauma-hemorrhage-induced liver injury in rats, at least in part, through melatonin receptor-related, p38 MAPK-dependent iNOS/HIF-1alpha pathway.NEW & NOTEWORTHY Trauma-hemorrhage resulted in a significant decrease in liver p38 MAPK activation and increase in nitrite oxide synthase (iNOS) and hypoxia-inducible factor (HIF)-1alpha expression. | Melatonin | nitric oxide synthase 2 | Rattus norvegicus |
| 7 | Administration of melatonin after trauma-hemorrhage normalized liver p38 MAPK phosphorylation and iNOS and HIF-1alpha expression, which was abolished by coadministration of SB203580 or luzindole. | Melatonin | nitric oxide synthase 2 | Rattus norvegicus |
| 8 | Melatonin prevents trauma-hemorrhage-induced liver injury in rats via the melatonin receptor-related, p38 MAPK-dependent iNOS/HIF-1alpha pathway. | Melatonin | nitric oxide synthase 2 | Rattus norvegicus |